Unique Proprietary Formulation – DON’T BE FOOLED BY IMITATIONS. Barmensen Labs, formulators of MAXODERM™, the original topical male enhancement formula, currently has a patent pending for this revolutionary male enhancement system.

Intensify Your Pleasure – MAXODERM’s topical formula goes to work fast increasing pleasure immediately. The very first time you use MAXODERM you’re going to experience an intense warming sensation which feels great.

New Found Confidence – our customers report incredible changes in erection quality and firmness. Most importantly MAXODERM has helped them live a more confident life in and out of the bedroom.

Rated #1 Male Enhancement System on the Market!

The normal physiology of achieving and maintaining an erection involves a complex interaction of physiological processes. Sexual arousal results in excitatory signals to the nervous system resulting in a release of nitric oxide in the corpus cavernosum (i.e., spongy erectile tissue of the penis). Nitric oxide diffuses into the smooth muscle cells lining the arteries of the corpus cavernosum, thereby relaxing vascular and trabecular smooth muscle cells. The relaxation of the smooth muscles lining the penile arteries allows these arteries of the corpus cavernosum to become engorged with blood, compressing the veins that drain blood from the penis and, as a result, trapping blood within the corpus cavernosum to produce an erection.

Solutions Targeting Sexual Arousal
The physiology of the male erectile tissue provides numerous points of interaction in which nervous or chemical manipulation may be used to overcome sexual dysfunction or enhance sexual responsiveness. For example commercially successful prescription drugs designed to interact with biochemistry of this system to treat erectile dysfunction include potent inhibitors of phosphodieterase type 5 enzymes (such as sildenafil), which function to prevent the ensuing subsidence of the corpus cavernosum. MAXODERM, on the other hand, is aimed at taking advantage of the increased production of nitric oxide.

The Production of Nitric Oxide Through Elevated L-arginine Supply
It has been found that the administration of L-arginine is another means of manipulating the biochemistry of the erectile processes to produce a greater nitric oxide-medicated erectile response. Nitric oxide is synthesized from L-arginine by nitric oxide synthase. The enzyme arginase regulates the L-arginine bioavailability to nitric oxide synthase by hydrolyzing L-arginine, thereby depleting the intracellular pool of L-arginine available to form nitric oxide. Therefore, the administration of L-arginine, arginase inhibitors and stimulants of nitric oxide synthase production have been used to enhance male sexual response and to treat sexual dysfunction in males through the enhanced production of nitric oxide. Of these treatments, the administration of L-arginine has been the most extensively studied and successful.

The administration of L-arginine is effective in increasing tumescence (engorgement with blood in erectile tissue) leading to increased sexual arousal. These effects are mediated through the nitric oxide pathway by the increased intracellular supply of L-arginine available for conversion of nitric oxide.

Methyl Nicotinate as an Absorption Enhancer
MAXODERM™ also includes methyl nicotinate, which is a potent vasodilator and mild irritant that has been used topically as a counterirritant in concentrations below 1%. This accounts for the immediate response experienced by the user. Specifically, the topical application of methyl nicotinate produces a vasodilatory response in the skin which spreads in a radial manner at a speed that is more rapid than can be accounted for in terms of simple diffusion and is therefore thought to involve mechanisms of active transport within the dermis. The methyl nicotinate in MAXODERM acts in the same manner to increase the absorption of L-arginine when applied to the penis.

Benefits of Targeted Delivery
Targeted delivery has been recently identified as an emerging alternative to orally administered products. Further, methyl nicotinate has been used topically for many years and recent research has shown that mixtures of ingredients with methyl nicotinate in a topical formulation leads to enhanced systemic absorption of the ingredients through the skin. Thus, MAXODERM presents a preferable delivery method that enhances the delivery of the desired ingredient (e.g., L-arginine) to the intended site of action while limiting the exposure of the rest of the body to the ingredients, thereby greatly decreasing the dose required for oral administration of the same ingredients.

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